Presentation
- Presents as a colourless solution stored at 4'C (i.e. fridge)
- Concentration of 4mg in 2ml (i.e. 2mg/ml)
Dosing
- A dose of 0.1m/kg produces intubating conditions in 90-150s
- Duration of block is 45 - 60 mins
Pancuronium
Pancuronium
- Pancuronium is a synthetic bisquaternary aminosteroid non-depolarising neuromuscular blocking agent
Distribution
- 10-40% protein bound
Metabolism
- Hepatic (35%) de-acetylation to:
- 3-hydroxy-pancuronium - is about 50% as potent as pancuronium
- 17-hydroxy-pancuronium
- 3,17-dihydroxy-pancuronium
Excretion
- Metabolites are excreted in the bile
- Unchanged drug is excreted in the urine
Cardiovascular
- Blocks cardiac muscarinic AChR causing tachycardia
- Has indirect sympathomimetic actions
- Blocks noradrenaline uptake at sympathetic post-ganglionic nerve endings
- Does not cause ganlgion blockade